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Related Concept Videos

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
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Updated: Jun 12, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Temporal PLGG and epilepsy.

Mony Benifla1, Shlomi Constantini2,3, Jonathan Roth2,3

  • 1The Pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel. Benifla1@gmail.com.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|September 17, 2024
PubMed
Summary
This summary is machine-generated.

Pediatric temporal lobe epilepsy (TLE) linked to tumors often becomes drug-resistant. Tumor resection offers significant seizure control benefits, but surgical decisions require careful consideration of developmental impacts and newer treatment options.

Keywords:
Epilepsy surgeryLow grade gliomaTemporal lobe epilepsy

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Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Temporal lobe epilepsy (TLE) in children is frequently associated with low-grade glial and glioneuronal tumors.
  • While tumors are often benign, the resulting TLE can become refractory to medication over time.

Purpose of the Study:

  • To review the management considerations for tumor-associated pediatric temporal lobe epilepsy.
  • To highlight the benefits of surgical intervention and discuss associated challenges.

Main Methods:

  • Literature review of studies on surgical and conservative treatments for pediatric TLE secondary to tumors.
  • Analysis of factors influencing surgical outcomes, including extent of resection and neurodevelopmental impact.

Main Results:

  • Tumor resection demonstrates significant advantages over conservative management for seizure control and medication reduction in pediatric TLE.
  • Surgical considerations include potential impacts on linguistic and neurocognitive development, especially in younger children.

Conclusions:

  • Surgical resection is a key treatment for tumor-associated pediatric TLE, offering better seizure outcomes.
  • Emerging treatments like laser ablation and biological therapies provide alternative or complementary options, particularly for tumors in eloquent brain regions.