Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nuclear Power02:36

Nuclear Power

7.7K
Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
7.7K
Nuclear Fission02:50

Nuclear Fission

9.6K
Many heavier elements with smaller binding energies per nucleon can decompose into more stable elements that have intermediate mass numbers and larger binding energies per nucleon—that is, mass numbers and binding energies per nucleon that are closer to the “peak” of the binding energy graph near 56. Sometimes neutrons are also produced. This decomposition of a large nucleus into smaller pieces is called fission. The breaking is rather random with the formation of a large...
9.6K
Directionality of Nuclear Transport01:42

Directionality of Nuclear Transport

3.2K
Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of  Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...
3.2K
Thermal Stress01:09

Thermal Stress

2.4K
If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...
2.4K
Nuclear Export01:42

Nuclear Export

3.6K
The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
3.6K
Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

632
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis.
632

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein quality control of thermosensitive nuclear transport factor importin α.

Journal of cell science·2026
Same author

Changes in importin levels promote nuclear proteasomal degradation of cell cycle-related proteins during THP-1 monocyte-to-macrophage differentiation.

FEBS letters·2025
Same author

Functional analysis of Hikeshi reveals physiological significance of nuclear Hsp70.

Current opinion in cell biology·2024
Same author

Single-nucleosome imaging unveils that condensins and nucleosome-nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes.

Nature communications·2024
Same author

The interaction between the import carrier Hikeshi and HSP70 is modulated by heat, facilitating the nuclear import of HSP70 under heat stress conditions.

Genes to cells : devoted to molecular & cellular mechanisms·2024
Same author

Reconstitution of nuclear envelope subdomain formation on mitotic chromosomes in semi-intact cells.

Cell structure and function·2024

Related Experiment Video

Updated: Jun 12, 2025

Laser-heating and Radiance Spectrometry for the Study of Nuclear Materials in Conditions Simulating a Nuclear Power Plant Accident
09:18

Laser-heating and Radiance Spectrometry for the Study of Nuclear Materials in Conditions Simulating a Nuclear Power Plant Accident

Published on: December 14, 2017

10.4K

Thermal Stress and Nuclear Transport.

Shingo Kose1, Yutaka Ogawa2, Naoko Imamoto3

  • 1Cellular Dynamics Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan. skose@riken.jp.

Advances in Experimental Medicine and Biology
|September 17, 2024
PubMed
Summary

Nuclear transport receptors (NTRs) are crucial for eukaryotic cell function. This review explores how heat stress impacts these pathways, focusing on Importin α and Hikeshi, highlighting the importance of diverse nuclear transport systems.

Keywords:
HSF1HSP (Heat shock protein)Heat stressHikeshiImportinImportin αNuclear transportStress granule

More Related Videos

Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

13.9K
Single-Molecule Imaging of Nuclear Transport
12:13

Single-Molecule Imaging of Nuclear Transport

Published on: June 9, 2010

13.3K

Related Experiment Videos

Last Updated: Jun 12, 2025

Laser-heating and Radiance Spectrometry for the Study of Nuclear Materials in Conditions Simulating a Nuclear Power Plant Accident
09:18

Laser-heating and Radiance Spectrometry for the Study of Nuclear Materials in Conditions Simulating a Nuclear Power Plant Accident

Published on: December 14, 2017

10.4K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

13.9K
Single-Molecule Imaging of Nuclear Transport
12:13

Single-Molecule Imaging of Nuclear Transport

Published on: June 9, 2010

13.3K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nuclear transport coordinates essential cellular events between the nucleus and cytoplasm.
  • While basic mechanisms are understood, the physiological roles of numerous nuclear transport receptors (NTRs) and their diverse pathways remain unclear.
  • Understanding how these pathways are regulated and their specific substrates is crucial for comprehending cellular function.

Purpose of the Study:

  • To review the effects of elevated temperatures, specifically thermal or heat stress, on nuclear transport systems.
  • To investigate the impact of heat stress on Importin α family members and the unique transport factor Hikeshi.
  • To emphasize the significance of diverse nuclear transport pathways in eukaryotic cells.

Main Methods:

  • Literature review focusing on studies investigating nuclear transport under thermal stress conditions.
  • Analysis of research on Importin α and Hikeshi in the context of heat stress.
  • Synthesis of current knowledge on the regulation and function of multiple nuclear transport pathways.

Main Results:

  • Nuclear transport systems are demonstrably affected by temperature increases (heat stress).
  • Specific nuclear transport receptors, including Importin α family members and Hikeshi, exhibit altered function or regulation under heat stress.
  • The diversity among the more than 20 identified NTRs suggests specialized roles that are impacted by environmental changes.

Conclusions:

  • Heat stress significantly impacts nuclear transport, affecting key receptors like Importin α and Hikeshi.
  • The distinct nature and regulation of multiple nuclear transport pathways are vital for cellular homeostasis under stress.
  • Further research into the specific functions and regulation of diverse NTRs is necessary to fully understand their physiological significance, especially during thermal stress.