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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.0K
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  11. The European Reference Genome Atlas: Piloting A Decentralised Approach To Equitable Biodiversity Genomics

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

Ann M Mc Cartney1, Giulio Formenti2,3, Alice Mouton3,4

  • 1Genomics Institute, University of California, Santa Cruz, CA, USA. anmmccar@ucsc.edu.

Npj Biodiversity
|September 17, 2024

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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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Novel Sequence Discovery by Subtractive Genomics
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Novel Sequence Discovery by Subtractive Genomics

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View abstract on PubMed

Summary
This summary is machine-generated.

The European Reference Genome Atlas (ERGA) Pilot Project tested a new distributed infrastructure for producing high-quality eukaryotic genomes. This initiative provides a scalable, equitable model for genomic data generation, crucial for biodiversity research.

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Novel Sequence Discovery by Subtractive Genomics
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Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

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Area of Science:

  • Genomics
  • Bioinformatics
  • Conservation Biology

Background:

  • A comprehensive genomic database of Earth's eukaryotes is essential for scientific discovery but remains largely incomplete.
  • The Earth BioGenome Project (EBP) aims to sequence all eukaryotic species, requiring robust infrastructure for genome production.
  • The European Reference Genome Atlas (ERGA) was established as the EBP's European node to develop a decentralized genome production model.

Purpose of the Study:

  • To implement and evaluate a novel, decentralized infrastructure for producing high-quality reference genomes.
  • To test the effectiveness of this infrastructure in scaling genome production while ensuring equity and inclusion.
  • To provide foundational insights for ERGA and inform other large-scale genomic resource projects.

Main Methods:

  • Launched a Pilot Project involving the production of reference genomes for 98 eukaryotic species.
  • Utilized a distributed infrastructure model across 33 European countries.
  • Assessed the infrastructure's scalability, equity, and inclusivity in genome production.

Main Results:

  • Successfully established and tested the first distributed reference genome production infrastructure.
  • Demonstrated the model's effectiveness in scaling high-quality genome production.
  • Gathered crucial outcomes and lessons learned regarding equitable and inclusive practices.

Conclusions:

  • The ERGA Pilot Project provides a solid foundation for future ERGA operations.
  • The project offers key learnings for transnational and national genomic resource initiatives, including the EBP.
  • A decentralized, equitable, and inclusive approach is effective for large-scale reference genome production.