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Updated: Jul 18, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
[Current research status of virus-like particle vaccine]
1Xi'an Key Laboratory of Pathogenic Microorganism/Tumor Immunity, Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, China.
Abstract:
Virus-like particles (VLPs) are self-assembled protein nanoparticles with repetitive antigen epitopes, which can stimulate immune response and do not contain viral genetic materials. VLPs has important research value and application potential in vaccine development, targeted drug delivery and bioengineering materials. In this review, the mechanism of VLPs vaccine induced immune responses is discussed. The existing VLPs expression systems are summarized. The research progress of VLPs vaccine in prevention and treatment of virus infection are summarized. This review provides general reference and guidance for the design and development of antiviral VLPs vaccine.
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