[Research progress of lipid-derived parameters in atherosclerotic cardiovascular disease]

Area of Science:

• Cardiovascular Medicine
• Clinical Biochemistry
• Lipid Metabolism

Background:

• Dyslipidemia is a major risk factor for atherosclerotic cardiovascular diseases.
• Traditional lipid metrics like LDL-C have limitations in comprehensive risk assessment.
• Early detection and intervention are crucial for reducing coronary heart disease (CHD) mortality.

Purpose of the Study:

• To review and synthesize lipid-derived parameters for enhanced dyslipidemia assessment.
• To highlight the clinical utility of novel lipid parameters beyond traditional markers.
• To provide a perspective on current research and clinical applications of these parameters.

Main Methods:

• Literature review of domestic and international guidelines and research.
• Delineation and synthesis of four key lipid-derived parameters.
• Analysis of physiological underpinnings and clinical relevance of lipid parameters.

Main Results:

• Lipid-derived parameters offer a more comprehensive risk assessment than singular lipid indices.
• Four specific parameters (AIP, non-HDL-C/HDL-C, ApoB/A1, LCI) show clinical promise.
• These parameters integrate multifactorial etiologies and physiological details of lipid metabolism.

Conclusions:

• Lipid-derived parameters provide deeper insights into dyslipidemia and cardiovascular risk.
• These novel metrics can improve the identification and management of patients at risk for CHD.
• Further clinical research supports the integration of these parameters into routine practice.