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  11. 6-year Follow-up On Migration Outcomes: A Randomised Clinical Trial Of Cemented Vitamin E-stabilised Highly Crosslinked Versus Standard Polyethylene Cup In Total Hip Arthroplasty

6-year follow-up on migration outcomes: a randomised clinical trial of cemented vitamin E-stabilised highly crosslinked versus standard polyethylene cup in total hip arthroplasty

Olof Sköldenberg1, Sebastian Mukka2, Martin Magneli1

  • 1Department of Clinical Sciences at Danderyd Hospital, Unit of Orthopaedics, Karolinska Institute, Stockholm, Sweden.

Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
|September 18, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

The vitamin E-doped highly cross-linked polyethylene (VEPE) cup showed significantly lower wear rates at 6 years in total hip arthroplasty. No significant difference in proximal migration or patient outcomes was observed compared to conventional polyethylene cups.

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Medical Engineering

Background:

  • Previous 2-year data indicated vitamin E-doped highly cross-linked polyethylene (VEPE) cups had higher proximal migration but lower wear rates than conventional polyethylene in total hip arthroplasty (THA).
  • This study presents a 6-year follow-up of the same patient cohort to evaluate long-term outcomes.

Purpose of the Study:

  • To compare the 6-year proximal migration, wear rate, and patient-reported outcomes of VEPE cups versus conventional polyethylene cups in cemented THA.
  • To assess the non-inferiority of VEPE cups regarding implant migration.

Main Methods:

  • A double-blinded, randomized controlled trial involving 66-year-old osteoarthritis patients undergoing THA.
  • Patients received either conventional polyethylene or VEPE cups (1:1 ratio).
Keywords:
Highly Crosslinked PolyethyleneRSARadiostereometric analysisRandomized clinical trial

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  • Primary endpoint: proximal implant migration via radiostereometric analysis (RSA); Secondary endpoints: wear rate and patient-reported outcome measurements (PROM).

    • Main Results:

    • No statistically significant difference in proximal migration was found between VEPE and control groups at 6 years.
    • VEPE cups demonstrated significantly lower wear rates (0.03 mm/year) compared to controls (0.07 mm/year).
    • No cup revisions occurred, and patient-reported outcomes were comparable between groups.

    Conclusions:

    • The vitamin E-doped highly cross-linked polyethylene cup shows no statistical or clinical difference in migration compared to conventional cups at 6 years.
    • VEPE cups exhibit significantly reduced wear rates, suggesting improved longevity.
    • Cemented VEPE cups are a viable and potentially superior option for total hip arthroplasty.
    Total hip replacement
    Vitamin E Highly Crosslinked Polyethylene