Clinical and Radiological Identification and Management of SAPHO Syndrome

Area of Science:

• Rheumatology
• Dermatology
• Autoinflammatory Diseases

Background:

• Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder.
• It affects individuals typically between 30 and 50 years old, with a prevalence of 1 in 10,000 in White populations.

Observation:

• A post-menopausal woman with SAPHO syndrome presented with acute foot and chest pain.
• She developed chronic pustular rashes on her feet, palms, neck, and abdomen concurrently with her pain.
• Radiological findings confirmed osteitis and sclerosis of the sternocostoclavicular joint and first rib.

Findings:

• The patient's presentation included simultaneous dermatological and musculoskeletal symptoms characteristic of SAPHO syndrome.
• Treatment with NSAIDs and IV corticosteroids effectively managed her pain and inflammatory symptoms.

Implications:

• Awareness of SAPHO syndrome's varied manifestations is essential for prompt diagnosis.
• Early diagnosis and treatment can significantly improve patient outcomes for this rare condition.