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Gene polymorphism impact on opioid analgesic usage
Sry Suryani Widjaja1, Muhammad Ichwan2, Balram Chowbay3
1Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Journal of Advanced Pharmaceutical Technology & Research
|September 18, 2024
Summary
Genetic variations influence how individuals respond to opioid pain relievers. This systematic review explores how gene polymorphism impacts opioid effectiveness and pharmacokinetics in pain management.
Area of Science:
- Pharmacogenomics
- Pain Management
- Clinical Pharmacology
Background:
- Opioids are crucial for managing acute, cancer, and malignant pain.
- Individual responses to opioids vary significantly.
- The impact of genetic polymorphism on opioid sensitivity is under-researched.
Purpose of the Study:
- To investigate the influence of gene polymorphism on analgesic use, specifically concerning opioids.
- To systematically review existing literature on the topic.
Main Methods:
- A systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards.
- Analysis of 13 publications focusing on gene polymorphism and opioid-based pain management.
- Review of studies involving oxycodone, fentanyl, tramadol, morphine, and other analgesics.
Main Results:
- Gene polymorphism significantly impacts the effectiveness of analgesics, particularly opioids.
- Genetic variations influence the pharmacokinetic profiles of various opioid medications.
- Evidence suggests a link between specific gene polymorphisms and patient response to opioid therapy.
Conclusions:
- Gene polymorphism plays a critical role in modulating analgesic mechanisms, especially for opioids.
- Understanding genetic variations can personalize opioid therapy for improved pain management.
- Further research into pharmacogenomics is essential for optimizing opioid analgesia.
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