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Published on: February 7, 2025
149
Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis: a bibliometrics
Juexian Wei1, Hengzong Mo2, Yuting Zhang3
1Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
World Journal of Emergency Medicine
|September 18, 2024
Summary
Endothelial dysfunction in sepsis (EDS) research is growing, with key areas including molecular mechanisms and therapeutic interventions. This bibliometric analysis maps the knowledge structure and identifies future research trends in EDS.
Area of Science:
- Critical Care Medicine
- Vascular Biology
- Pathophysiology
Background:
- Endothelial dysfunction in sepsis (EDS) is a key feature of septic organ failure, leading to vascular leakage and systemic injury.
- Understanding the mechanisms of EDS is crucial for treating sepsis-induced organ damage.
- Bibliometric analysis provides a novel approach to map the knowledge landscape of EDS.
Purpose of the Study:
- To provide a comprehensive overview of the knowledge structure in EDS research.
- To identify research trends and key areas within the field of EDS.
- To analyze publication output, authorship, and keyword co-occurrence.
Main Methods:
- Bibliometric analysis of 4,536 publications from 2003-2023 in the Web of Science Core Collection.
- Utilized R-bibliometrix, CiteSpace, and VOSviewer for data extraction and visualization.
- Analyzed citation frequency, authorship, keywords, h-index, and average citations per item.
Main Results:
- The USA, China, Germany, Canada, and Japan are leading contributors to EDS research.
- Harvard University is the most prolific institution; Professor Jong-Sup Bae's team is highly influential.
- Prominent research areas include protein C, tissue factor, thrombin, glycocalyx, acute kidney injury, syndecan-1, and biomarkers.
Conclusions:
- Research interest in endothelial dysfunction in sepsis is increasing.
- Future research should focus on molecular mechanisms, signaling pathways, and endothelial repair.
- Investigating endothelial cell interactions and developing therapeutic interventions are crucial.
