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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by

Shinichiro Yamada¹, Yuji Morine¹, Tetsuya Ikemoto¹

¹Department of Surgery, Tokushima University Hospital, Tokushima University, Tokushima 770-8503, Japan.

Oncology Letters

|September 18, 2024

Summary

Apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI) can help evaluate gallbladder tumors. Lower ADC values indicate malignancy and poorer prognosis in gallbladder cancer patients.

Keywords:

apparent diffusion coefficient gallbladder tumor magnetic resonance imaging malignancy prognostic prediction

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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

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Published on: March 29, 2019

Area of Science:

Oncology
Radiology
Medical Imaging

Background:

Gallbladder tumors require accurate diagnostic tools for malignancy assessment.
Diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) offers insights into tissue microstructure.

Purpose of the Study:

To investigate the utility of apparent diffusion coefficient (ADC) values in evaluating malignancy and prognosis of gallbladder tumors.
To correlate ADC values with clinicopathological factors in gallbladder cancer.

Main Methods:

Retrospective analysis of 63 patients (33 benign, 30 cancer) who underwent surgical resection for gallbladder tumors.
Acquisition of mean ADC values using DWI-MRI.
Comparison of ADC values between benign and malignant tumors, and early vs. advanced gallbladder cancer.
Stratification of advanced gallbladder cancer cases into ADC-High and ADC-Low groups for survival analysis.

Main Results:

Significantly lower ADC values were observed in advanced and early gallbladder cancer compared to benign tumors (P<0.05).
The ADC-Low group in advanced gallbladder cancer showed a trend towards higher rates of advanced stage disease (P=0.09).
Disease-free survival and overall survival (OS) were significantly worse in the ADC-Low group compared to the ADC-High group (P<0.01).
Multivariate analysis identified poor differentiation and low ADC value as independent prognostic factors for OS.

Conclusions:

ADC values derived from DWI-MRI show potential for differentiating malignant from benign gallbladder tumors.
Low ADC values are associated with poorer prognosis and advanced disease in gallbladder cancer.
ADC measurements may serve as a valuable non-invasive biomarker for gallbladder tumor evaluation.