Sequencing technology in sarcopenia: current research progress and future trends.

Area of Science:

• Muscle physiology and pathology
• Genomics and molecular biology
• Disability studies

Background:

• Muscle atrophy is a widespread condition causing weakness and motor function decline, contributing significantly to disability.
• Genomic research methods like transcriptomics, proteomics, and metabolomics are crucial for understanding disease pathology.
• While combinatorial research in muscle atrophy is increasing, bibliometric and visual analyses are lacking.

Purpose of the Study:

• To conduct the first bibliometric and visual analysis of research on muscle atrophy.
• To systematically review and summarize scholarly contributions in the field.
• To identify trends and provide future research prospects.

Main Methods:

• Systematic literature search of muscular dystrophy histological studies from 2000 onwards in the Web of Science core database.
• Data analysis and visualization using CiteSpace, VosViewer, and R software.
• Statistical analysis of publication output, co-authorship, institutional, and country contributions.

Main Results:

• A total of 141 publications were identified, showing a year-on-year increase.
• Research involved 1031 co-authors from 361 institutions across 31 countries, published in 92 journals.
• Publications received 6286 citations from 1383 journals, with the United States leading in output and citations.

Conclusions:

• This study presents the first bibliometric and visual analysis of muscle atrophy research.
• It summarizes existing scholarly work and identifies key contributors.
• The findings offer insights for future research directions in understanding and combating muscle atrophy.