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Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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  11. Understanding The Mechanisms Of Fatigue In Multiple Sclerosis: Linking Interoception, Metacognition And White Matter Dysconnectivity

Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity

Iulia Danciut1,2, Charlotte L Rae3, Waqar Rashid4

  • 1Clinical Imaging Sciences Centre, Department of Clinical Neuroscience, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9RR, UK.

Brain Communications
|September 18, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Cognitive fatigue in multiple sclerosis is linked to impaired interoceptive insight, not general interoception or metacognition. White matter damage worsens this insight and fatigue.

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Pathological fatigue is a debilitating symptom in multiple sclerosis (MS), significantly impacting quality of life and employment.
  • The underlying neural mechanisms of cognitive fatigue in MS remain poorly understood.
  • Interoception and metacognition are critical brain functions potentially affected by MS pathology.

Purpose of the Study:

  • To investigate the neural correlates of interoception and metacognition in modulating cognitive fatigue in MS patients.
  • To test hypotheses that fatigue results from reduced interoceptive accuracy, reduced interoceptive insight, or reduced global metacognition.
  • To explore associations between these behavioral measures and white matter microstructure using advanced MRI techniques.

Main Methods:

Keywords:
cognitive fatiguediffusion MRIinteroceptive insightmultiple sclerosis

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Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

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5.8K
A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

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276
  • Cross-sectional study involving 71 relapsing-remitting MS patients.
  • Behavioral assessments included heartbeat tracking/discrimination for interoception and visual/memory tasks for metacognition.
  • Quantitative MRI, including diffusion tensor imaging and quantitative magnetization transfer, assessed white matter microstructure.

    • Main Results:

    • Higher odds of cognitive fatigue were associated with lower interoceptive insight (P=0.03).
    • No significant relationships were found between fatigue and general interoception or metacognition.
    • Widespread white matter damage, particularly loss of neurite density, was negatively associated with cognitive fatigue.

    Conclusions:

    • Cognitive fatigue in MS is specifically linked to impairments in interoceptive metacognition, rather than general interoception or metacognition.
    • White matter integrity plays a crucial role, with poorer structure correlating with reduced interoceptive insight and increased fatigue.
    • Findings suggest a specific neural basis for cognitive fatigue in MS involving interoceptive metacognitive deficits within damaged white matter networks.
    white matter