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Aficamten in non-obstructive hypertrophic cardiomyopathy: Unlocking new horizons?

Maddalena Rossi1,2, Enrico Fabris1,2, Gianfranco Sinagra1,2

  • 1Cardiothoracovascular Department, Center for Diagnosis and Treatment of Cardiomyopathies, Azienda Sanitaria Universitaria Giuliano-Isontina, University of Trieste, Trieste, Italy.

European Journal of Heart Failure
|September 18, 2024
PubMed
Abstract

No abstract available in PubMed .

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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