Safeguarding Patients with End-Stage Kidney Disease From Climate-driven Extreme Heat and Hurricanes

Rebecca L Shakour1, Zain Mithani2, Jeffrey B Kopp3

  • 1University of Miami, Miller School of Medicine, Miami, Florida, USA.

Abstract

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Proximal Convoluted Tubule (PCT):
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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Renal Regulation of Acid-Base Balance01:29

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