Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

268
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
268
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Human Genetics01:28

Human Genetics

542
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
542
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

3.0K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
3.0K
Polygenic Traits01:18

Polygenic Traits

65.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.6K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Physical activity patterns from mid- to late adulthood and risk of sarcopenia in older adults: the HUNT study.

BMC geriatrics·2026
Same author

Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trøndelag Health Study.

European journal of preventive cardiology·2026
Same author

Submaximal measures of fitness and left ventricular size: associations and utility in differentiating physiological and pathological enlargement.

European heart journal. Imaging methods and practice·2026
Same author

Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.

Scandinavian journal of medicine & science in sports·2026
Same author

Publisher Correction: Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.

Nature genetics·2026

Related Experiment Video

Updated: Jun 12, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K

Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.

Karsten Øvretveit1, Emma M L Ingeström2, Michail Spitieris1,3

  • 1HUNT Center for Molecular and Clinical Epidemiology (MCE), Department of Public Health and Nursing Norwegian University of Science and Technology (NTNU) Trondheim Norway.

Journal of the American Heart Association
|September 18, 2024
PubMed
Summary

Genetic predisposition to high blood pressure (BP) may increase vulnerability to environmental factors, but these risks are modifiable. Gene-environment interactions highlight potential for personalized hypertension prevention and management.

Keywords:
blood pressurecardiorespiratory fitnesscardiovascular diseasegene–environment interactionspolygenic risk scores

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K
Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

22.1K

Related Experiment Videos

Last Updated: Jun 12, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K
Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

22.1K

Area of Science:

  • Genetics and Environmental Health
  • Cardiovascular Disease Research
  • Public Health Genomics

Background:

  • Essential hypertension arises from complex genetic and environmental interactions.
  • Established lifestyle factors (obesity, alcohol, tobacco, diet, activity) impact blood pressure (BP).
  • Polygenic risk scores (PRS) for BP traits show significant phenotypic variation, but gene-environment interactions remain unclear.

Purpose of the Study:

  • To investigate gene-environment interactions in hypertension using genome-wide polygenic risk scores (PRS) and extensive environmental exposures.
  • To identify specific lifestyle and biomarker interactions with genetic predisposition to systolic and diastolic BP.

Main Methods:

  • Utilized genotype and phenotype data from the HUNT study (49,234 participants).
  • Modeled gene-environment interactions between genome-wide PRS for systolic BP (SBP) and diastolic BP (DBP) and 125 environmental exposures.
  • Assessed independent associations of environmental factors with SBP and DBP, and identified significant gene-environment interactions (P < 2x10^-4).

Main Results:

  • 108 environmental exposures independently associated with SBP; 100 with DBP.
  • Identified 12 significant gene-environment interactions for SBP-PRS and 4 for DBP-PRS.
  • Found gene-dependent effects of cardiorespiratory fitness, diet, tobacco use, serum cholesterol, creatinine, and alkaline phosphatase on BP.

Conclusions:

  • Genetically susceptible individuals may be more vulnerable to acquired risk factors for hypertension, but these influences are modifiable.
  • Gene-environment interactions suggest that combining genetic data with lifestyle assessments can improve hypertension risk stratification.
  • Gene-environment-informed risk modeling offers potential for enhanced hypertension prevention and management strategies.