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Torsemide in Edema Associated with Chronic Kidney Disease
Deodatta Chafekar1, Pinaki Mukhopadhyay2, Niranjan Ambekar3
1Director and Consultant Nephrologist, Department of Nephrology, Supreme Kidney Care; Professor, Department of Medicine, Dr Vasantrao Pawar Medical College, Hospital and Research Centre, Maharashtra University of Health Sciences (MUHS), Nashik, Maharashtra, India, Corresponding Author.
Abstract:
Torsemide is a loop diuretic used to manage edema associated with chronic kidney disease (CKD) and acute kidney injury (AKI). It acts by inhibiting sodium and chloride ions reabsorption in the ascending limb of the loop of Henle, thereby increasing urine output and reducing fluid accumulation. Compared to other diuretics, torsemide has an extended duration of action, higher bioavailability, and its elimination route is primarily through the hepatic route, making it effective in patients with CKD and AKI. Clinical studies indicate that torsemide can improve symptoms of fluid overload and potentially enhance renal function.
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