Related Experiment Video
Updated: Jun 12, 2025

11:55
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
11.7K
A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive
Angela Serrano-Sanchez1, Matthew Rice1, Joseph Cassar1
1School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK. j.l.ortega-roldan@kent.ac.uk.
Abstract:
Quantifying small molecule uptake across a biological membrane of a target cell is crucial for the development of efficacious and selective drugs. However, current methods to obtaining such data are not trivial. Herein, we present an accessible, higher-throughput (20 minutes), 1H NMR spectroscopy assay, which enables the quantification of small molecule phospholipid passive membrane permeation and membrane adhesion parameters.

