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Related Experiment Videos

Buprenorphine effects on cigarette smoking.

N K Mello, S E Lukas, J H Mendelson

    Psychopharmacology
    |January 1, 1985
    PubMed
    Summary
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    Buprenorphine, an opioid medication, significantly increased cigarette smoking in heroin addicts. This suggests buprenorphine acts primarily as an agonist, similar to heroin, in promoting smoking behavior.

    Area of Science:

    • Addiction Medicine
    • Clinical Pharmacology
    • Behavioral Science

    Background:

    • Opioid medications are frequently used in addiction treatment.
    • Smoking is highly prevalent among individuals with opioid use disorder.
    • The relationship between buprenorphine and smoking behavior requires further elucidation.

    Purpose of the Study:

    • To investigate the effect of buprenorphine on cigarette smoking rates in heroin addicts.
    • To compare smoking behavior during buprenorphine treatment versus heroin self-administration.
    • To determine if buprenorphine exhibits agonist or antagonist effects on smoking.

    Main Methods:

    • Seven heroin addicts were maintained on buprenorphine for 24 days.
    • Cigarette smoking frequency was measured during buprenorphine induction and maintenance phases.

    Related Experiment Videos

  • A placebo group (n=6) received placebo buprenorphine and self-administered heroin.
  • Intercigarette intervals and cigarette requests were analyzed.

    • Main Results:

    • Buprenorphine administration significantly increased cigarette smoking compared to baseline.
    • Increased smoking correlated with ascending buprenorphine doses (≥2.0 mg/day).
    • Smoking rates were highest during high-dose buprenorphine maintenance and heroin self-administration.
    • Placebo buprenorphine alone did not alter smoking rates.

    Conclusions:

    • Buprenorphine administration is associated with a significant increase in cigarette smoking.
    • These findings suggest buprenorphine exerts primarily agonist effects on smoking behavior.
    • Opioid agonist effects may contribute to the high rates of smoking in individuals on opioid maintenance therapy.