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Related Concept Videos

Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

925
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

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Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
1.8K
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

564
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
564
Complexation Equilibria: Overview01:23

Complexation Equilibria: Overview

642
Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...
642
Basicity of Heterocyclic Aromatic Amines01:25

Basicity of Heterocyclic Aromatic Amines

5.7K
Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
5.7K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

475
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
475

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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In(III) pyridinecarboxylate complexes: Composition, solution equilibria estimation, bioevaluation and interactions

Michaela Rendošová1, Róbert Gyepes2, Adrián Gucký3

  • 1Department of Inorganic Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovak Republic.

Journal of Inorganic Biochemistry
|September 18, 2024
PubMed
Summary

New indium(III) complexes with picolinic acid (InPic) and dipicolinic acid (InDpic) show promising antimicrobial and anticancer activities. InPic demonstrated higher efficacy against S. aureus and MDA-MB-231 cancer cells, and both complexes effectively bind to human serum albumin.

Keywords:
AnticancerAntimicrobialHSA bindingIn(III) complexesPotentiometryPyridinecarboxylatesStability

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Biochemistry

Background:

  • Indium(III) complexes are explored for their potential biological applications.
  • Picolinic acid and dipicolinic acid are versatile ligands for metal complexation.
  • Understanding metal-ligand interactions is crucial for developing new therapeutic agents.

Purpose of the Study:

  • To synthesize and characterize novel indium(III) pyridinecarboxylate complexes.
  • To investigate the speciation, stability, and biological activity of these complexes.
  • To elucidate the interaction mechanism of the complexes with human serum albumin (HSA).

Main Methods:

  • One-step synthesis of indium(III) complexes: In(Pic) and In(Dpic).
  • Structural and physicochemical characterization: X-ray diffraction, potentiometry, 1H NMR spectroscopy.
  • Biological assays: Antimicrobial and anticancer activity tests; HSA binding studies using fluorescence and CD spectroscopy.

Main Results:

  • Two indium(III) complexes, [In(Pic)2(NO3)(H2O)] (InPic) and [In(HDpic)(Dpic)(H2O)2]·5H2O (InDpic), were successfully synthesized.
  • Complex speciation and stability were confirmed in solution; InPic showed greater antimicrobial and anticancer efficacy.
  • Both complexes bind to HSA, with InPic exhibiting stronger binding, leading to conformational changes in HSA.

Conclusions:

  • The synthesized indium(III) pyridinecarboxylates exhibit significant biological potential.
  • InPic demonstrates superior activity against tested bacteria and cancer cells.
  • The study provides insights into the binding interactions of these complexes with HSA, relevant for drug development.