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[Hemorheologic and blood coagulation studies in 94 patients with chronic obstructive peripheral arterial disease]
Insights
Patients with chronic arterial occlusive disease often exhibit hyperviscosity and hypercoagulability. Key indicators include elevated hematocrit, increased platelet aggregation, and reduced erythrocyte filterability, worsening with disease progression.
Area of Science:
- Vascular Medicine
- Hematology
Context:
- Chronic arterial occlusive disease (CAOD) affects peripheral circulation.
- Understanding hemorheological and hemocoagulative status is crucial for managing CAOD.
Purpose:
- To assess hemorheological and hemocoagulative parameters in 94 CAOD patients.
- To identify key biomarkers associated with disease severity.
Summary:
- Analysis of 94 CAOD patients revealed elevated hematocrit (56%), increased Katz index (61.7%), and higher platelet aggregation.
- Antithrombin III (ATIII) showed a trend towards lower values.
- Erythrocyte filterability decreased with advanced clinical stages, indicating impaired blood flow.
Impact:
- Findings confirm hyperviscosity and hypercoagulability in CAOD patients.
- Highlights the role of specific hematological markers in disease progression.
- Provides insights for potential therapeutic targets to improve blood flow and reduce clotting risk.
Abstract:
During the last three years we have analyzed, in 94 patients with chronic arterial occlusive disease, in order to assess the hemorheological and hemocoagulative balance, the following parameters: prothrombin time, partial thromboplastin time, antithrombin III, antiplasmin, fibrinogen, factor VIII, erythrocyte sedimentation rate, platelet aggregation, erythrocyte filterability and hematocrit values. The main findings were: in 56 patients the hematocrit value was higher than 44%; Katz index was above normal values in 61.7% of the cases; ATIII showed a trend to lower values; platelet aggregation was increased; no significant variations in comparison to normal values were found in FVIII, antiplasmin levels, prothrombin time and partial thromboplastin time. Erythrocyte filterability values were decreased at a level as lower as more advanced was the clinical stage of the disease. These findings show, in agreement with those of other authors, the presence of hyperviscosity and hypercoagulative state in patients with chronic arterial occlusive disease.