Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin-free pineal substance, an equilibrating hormone?

E Damian

    Endocrinologie
    |April 1, 1985
    PubMed
    Summary

    Melatonin-free pineal extract demonstrates a regulating role by normalizing biochemical levels. This extract corrected hormonal imbalances and cholesterol levels in animal models, suggesting its equilibrating function in the pineal gland.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Urinary elimination of 17-ketosteroids in patients of rheumatism treated with iodized mineral water and thyroid extract].

    Probleme de reumatologie·2014
    Same author

    Purification and physico-chemical characterization of the antigonadotropic fractions obtained by ultrafiltration from the pineal extract.

    Endocrinologie·1991
    Same author

    Neurophysins in some mammalian species.

    Endocrinologie·1991
    Same author

    The rat testis--a source of hypothalamic neuropeptide-like factor.

    Endocrinologie·1990
    Same author

    [Enzymatic aspects of severely acute diarrheal disease in infants].

    Revista de pediatrie, obstetrica si ginecologie. Pediatria·1989
    Same author

    The antisteroid, antigonadotropic and metabolism-regulation activity of the pineal gland.

    Endocrinologie·1989

    Area of Science:

    • Endocrinology
    • Biochemistry
    • Pineal Gland Research

    Background:

    • The pineal gland's role in hormonal regulation is complex.
    • Melatonin is a key pineal hormone, but non-melatonin components also influence physiology.
    • Understanding the pineal extract's broader regulatory functions is crucial.

    Purpose of the Study:

    • To investigate the physiological effects of a melatonin-free pineal extract.
    • To determine the extract's role in regulating specific biochemical and hormonal indices.
    • To assess the extract's ability to correct experimentally induced imbalances.

    Main Methods:

    • Administration of melatonin-free pineal extract to rabbits and rats under basal and stimulated conditions.
    • Measurement of urinary 17-ketosteroids (17-Ks), cholesterol, hepatic cholesterol, ascorbic acid, serum LH, prolactin, and testicular tissue components (DNA, RNA, proteins).
    • Evaluation of extract's effects with and without hormonal stimulation (HCG, GnRH, TRH).

    Main Results:

    • Pineal extract significantly lowered urinary 17-Ks and cholesterolemia in rabbits, and cholesterolemia, hepatic cholesterol, and ascorbic acid in rats under basal conditions.
    • The extract corrected experimentally lowered biochemical indices towards basal levels.
    • Under HCG stimulation, the extract counteracted decreases in serum and testicular cholesterol, and testicular DNA, RNA, and proteins.
    • The extract normalized serum LH and prolactin levels when GnRH and TRH respectively induced unexpected decreases.

    Conclusions:

    • Melatonin-free pineal extract exhibits a significant equilibrating and regulatory role in physiological processes.
    • The extract can normalize or correct various biochemical and hormonal parameters.
    • These findings highlight the importance of non-melatonin pineal components in endocrine regulation.

    Related Experiment Videos