Targeting renal damage: The ACE2/Ang-(1-7)/mas axis in chronic kidney disease

Area of Science:

• Nephrology
• Cardiovascular Research
• Pharmacology

Background:

• The renin-angiotensin system (RAS) significantly impacts chronic kidney disease (CKD) progression.
• Classical ACE/Ang II/AT1 axis activation worsens renal damage, inflammation, and fibrosis.
• The ACE2/Ang-(1-7)/Mas axis presents a potential protective mechanism in CKD.

Purpose of the Study:

• To comprehensively review the role of the ACE2/Ang-(1-7)/Mas axis in CKD pathogenesis.
• To systematically examine therapeutic molecules and agents targeting this specific RAS axis.
• To identify potential strategies for delaying or halting CKD progression.

Main Methods:

• Literature review of studies on the ACE2/Ang-(1-7)/Mas axis in CKD.
• Analysis of research on pharmaceutical agents targeting this pathway.
• Synthesis of findings to evaluate therapeutic potential.

Main Results:

• The ACE2/Ang-(1-7)/Mas axis demonstrates renoprotective effects in various CKD models.
• Several molecules and drugs targeting this axis show promise in preclinical studies.
• Modulating this axis offers a potential therapeutic avenue for managing CKD.

Conclusions:

• The ACE2/Ang-(1-7)/Mas axis is a critical target for novel CKD therapies.
• Further research into targeting this pathway could lead to more effective treatments.
• Interventions focused on this axis may help preserve renal function in CKD patients.