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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Jun 12, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods.

Kristen M Beavers1, Brianna R Wolle1, Jamy D Ard2

  • 1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.

Contemporary Clinical Trials
|September 18, 2024
PubMed
Summary

This study investigates how resistance training and bisphosphonates affect bone density in older adults during weight loss. Findings will help optimize strategies to preserve bone health while reducing body fat.

Keywords:
AgingBoneExercisePharmacotherapyWeight loss

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Area of Science:

  • Gerontology
  • Bone Metabolism
  • Obesity Research

Background:

  • Intentional weight loss (WL) in older adults with obesity improves comorbidities but can decrease bone mineral density (BMD), increasing fracture risk.
  • Optimizing WL interventions to preserve musculoskeletal health is crucial for this population.
  • The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial addresses this by examining strategies to mitigate WL-associated bone loss.

Purpose of the Study:

  • To compare the independent and combined effects of resistance training (RT) and bisphosphonate use on bone loss during a 12-month dietary WL intervention.
  • To evaluate the impact of these interventions on skeletal integrity in older adults.

Main Methods:

  • 308 older adults (≥60 years) with obesity and an indication for WL and bisphosphonate use participated.
  • Participants received a group-mediated dietary intervention targeting 8-10% WL.
  • Randomization to four groups: no RT + placebo, RT + placebo, no RT + bisphosphonate, or RT + bisphosphonate.

Main Results:

  • Primary outcome: total hip areal BMD measured by DXA.
  • Secondary outcomes: femoral neck and lumbar spine aBMD, HRpQCT bone assessments, and bone turnover biomarkers.

Conclusions:

  • The BEACON trial will provide critical insights into optimizing skeletal integrity during weight loss in older adults.
  • It investigates scalable interventions to maximize fat loss while minimizing harm to the musculoskeletal system.