Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

130
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
130
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

134
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
134
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

184
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
184
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

186
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
186

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associated factors of possible consultation behavior for obstructive sleep apnea among male Japanese workers: a retrospective analysis.

Sleep and biological rhythms·2026
Same author

Differences in brain functional connectivity between autonomous sensory meridian response and classical music.

Frontiers in neuroscience·2026
Same author

Real-world data on patients with HR+, HER2- early breast cancer prescribed with abemaciclib adjuvant therapy for 2 years in Japan.

Future oncology (London, England)·2026
Same author

Optimizing preoperative planning for total hip arthroplasty using random forest models to predict stem size and compatibility.

BMC musculoskeletal disorders·2026
Same author

Exploring the impact of a data-feedback workshop on injury trends in a regional collegiate American football league in Japan.

Frontiers in sports and active living·2026
Same author

The impact of the COVID-19 pandemic on the incidence and clinical profiles of Guillain-Barré syndrome in Japan.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Jun 12, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.7K

Obstructive sleep apnea syndrome attenuated high-density lipoprotein function.

Yasuhiro Endo1, Manami Teramoto2, Junko Arakawa2

  • 1Division of Anti-aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan (Drs Endo, Teramoto, Arakawa, Suenaga, Sasaki, and Ikewaki); Division of Environmental Medicine, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama, Japan (Dr Endo).

Journal of Clinical Lipidology
|September 18, 2024
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) impairs high-density lipoprotein (HDL) function, indicated by reduced cholesterol efflux capacity (CEC). Increased orosomucoid 1 (ORM1) levels may contribute to this dysfunction, though CPAP therapy did not improve CEC.

Keywords:
ApolipoproteinsCholesterol/efflux capacityLipidLipid/EffluxLipoprotein

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

718
Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

5.9K

Related Experiment Videos

Last Updated: Jun 12, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.7K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

718
Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

5.9K

Area of Science:

  • Cardiovascular Disease Research
  • Sleep Medicine
  • Lipid Metabolism and Atherosclerosis

Background:

  • Obstructive sleep apnea (OSA) is a significant risk factor for cardiovascular disease.
  • High-density lipoproteins (HDLs) possess anti-atherogenic properties, including cholesterol efflux capacity (CEC).
  • The HDL proteome is altered in patients with coronary artery disease.

Purpose of the Study:

  • To investigate if OSA alters the HDL proteome, thereby impairing HDL function.
  • To determine if continuous positive airway pressure (CPAP) therapy can alleviate OSA-induced HDL dysfunction.

Main Methods:

  • A cross-sectional study enrolled 115 patients with suspected OSA.
  • An interventional study included 34 patients with moderate-to-severe OSA treated with CPAP for 12 weeks.
  • HDL proteome analysis was performed in 10 OSA patients; CEC and serum orosomucoid 1 (ORM1) levels were measured.

Main Results:

  • Patients with sleep apnea syndrome (SAS; apnea-hypopnea index [AHI] ≥ 5) exhibited significantly lower CEC compared to non-SAS individuals (AHI < 5).
  • Minimal pulse oxygen saturation (MinSpO2) was positively correlated with CEC.
  • CPAP therapy did not significantly alter CEC; elevated ORM1 levels were inversely associated with CEC, independent of HDL-cholesterol and C-reactive protein.

Conclusions:

  • HDL function, specifically CEC, is impaired in patients with OSA.
  • CPAP therapy did not improve CEC in this study cohort.
  • An altered HDL proteome, characterized by increased ORM1, is associated with impaired HDL function in OSA patients.