Analysis of the Relationship Between Primary Tumor Site and Clinicopathological Characteristics and Survival Prognosis of Breast Cancer Patients Based on SEER Database
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View abstract on PubMed
Summary
This summary is machine-generated.The primary tumor site in breast cancer (BC) significantly impacts survival. Central portion BC patients face worse outcomes due to advanced stage and lymph node involvement, highlighting the need for early diagnosis.
Area Of Science
- Oncology
- Epidemiology
Background
- Breast cancer (BC) is a leading cause of mortality worldwide.
- Understanding factors influencing BC prognosis is crucial for effective treatment strategies.
Purpose Of The Study
- To investigate the association between primary tumor site and clinicopathological features in breast cancer patients.
- To analyze the impact of primary tumor location on overall survival (OS) and breast cancer-specific survival (BCSS).
Main Methods
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database, analyzing 193,043 BC patients.
- Categorized patients by primary tumor site and employed Kaplan-Meier curves and Cox regression models.
- Developed nomograms for predicting OS and BCSS, particularly for central portion BC.
Main Results
- The upper outer quadrant was the most common BC site (52.60%).
- Patients with central portion tumors exhibited poorer OS and BCSS compared to other sites.
- Subgroup analyses indicated that age, T stage, and N stage influenced survival differences.
Conclusions
- Primary tumor site is a significant prognostic factor in breast cancer, influenced by patient age and tumor stage.
- Central portion BC is linked to worse prognosis due to factors like older age, advanced T stage, and lymph node metastasis.
- Early diagnosis and timely intervention are recommended to improve survival rates for central portion breast cancer.
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