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Membrane Lipids

Membrane Lipids

Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

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Formula with large, milk phospholipid-coated lipid droplets in late-moderate preterm infants: a double-blind RCT.

Andreas Kakaroukas^1,2, Marieke Abrahamse-Berkeveld³, Louise Hayes⁴

¹Newcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, UK.

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|September 18, 2024

Summary

A new concept infant formula showed similar growth to standard formula in preterm infants. This formula is a safe alternative for parents choosing formula feeding for their late and moderate preterm infants.

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Area of Science:

Neonatal Nutrition
Pediatric Gastroenterology
Infant Growth and Development

Background:

Limited evidence exists on optimal infant formula for late and moderate preterm (LMPT) infants when breastfeeding is not possible.
Preterm infant nutrition is critical for growth and development.
Novel infant formulas aim to mimic breast milk composition and benefits.

Purpose of the Study:

To evaluate the growth, safety, and tolerance of a novel concept infant formula (IF) in LMPT infants.
To demonstrate non-inferiority of daily weight gain compared to standard IF.
To compare growth outcomes against a breastfed reference group.

Main Methods:

A randomized controlled trial (RCT) involving LMPT infants.
Infants were randomized to either concept IF (n=21) or standard IF (n=20) around term equivalent age.
A reference group of 41 breastfed (BF) infants was included for comparison.

Main Results:

Non-inferiority of daily weight gain could not be demonstrated due to low recruitment, but the concept formula was comparable to the breastfed group.
Head circumference gain was larger in the concept formula group, though not statistically significant.
Growth and body composition were similar between concept and breastfed groups; both formulas were well-tolerated.

Conclusions:

The concept infant formula appears to be a safe alternative for LMPT infants when formula feeding is chosen.
Further large-scale trials are necessary to confirm findings on head growth and body composition.
This study provides preliminary evidence supporting the use of the novel formula in specific infant populations.