A comparative evaluation of deep learning approaches for ophthalmology

There is a growing number of publicly available ophthalmic imaging datasets and open-source code for Machine Learning algorithms. This allows ophthalmic researchers and practitioners to independently perform various deep-learning tasks. With the advancement in artificial intelligence (AI) and in the field of imaging, the choice of the most appropriate AI architecture for different tasks will vary greatly. The best-performing AI-dataset combination will depend on the specific problem that needs to be solved and the type of data available. The article discusses different machine learning models and deep learning architectures currently used for various ophthalmic imaging modalities and for different machine learning tasks. It also proposes the most appropriate models based on accuracy and other important factors such as training time, the ability to deploy the model on clinical devices/smartphones, heatmaps that enhance the self-explanatory nature of classification decisions, and the ability to train/adapt on small image datasets to determine if further data collection is worthwhile. The article extensively reviews the existing state-of-the-art AI methods focused on useful machine-learning applications for ophthalmology. It estimates their performance and viability through training and evaluating architectures with different public and private image datasets of different modalities, such as full-color retinal images, OCT images, and 3D OCT scans. The article is expected to benefit the readers by enriching their knowledge of artificial intelligence applied to ophthalmology.