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lncRNA HOTAIR and Cardiovascular diseases
Sina Taghvimi1, Elahe Soltani Fard2,3, Seyyed Hossein Khatami4
1Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Functional & Integrative Genomics
|September 18, 2024
Summary
Long non-coding RNAs (lncRNAs), like HOTAIR, are emerging as key players in cardiovascular diseases (CVDs). This research reviews HOTAIR
Area of Science:
- Molecular Biology
- Cardiology
- Genetics
Background:
- Cardiovascular diseases (CVDs) are a leading cause of global mortality.
- Understanding molecular mechanisms is crucial for targeted CVD therapeutics.
- Long non-coding RNAs (lncRNAs) play significant roles in disease pathogenesis.
Purpose of the Study:
- To provide a comprehensive overview of HOTAIR's molecular mechanisms in CVDs.
- To explore HOTAIR's potential as a biomarker and therapeutic target for CVDs.
- To summarize recent advancements in HOTAIR research for cardiovascular disorders.
Main Methods:
- Literature review of recent studies on HOTAIR and CVDs.
- Analysis of HOTAIR's epigenetic regulatory functions.
- Investigation of HOTAIR's role in cardiovascular pathophysiological processes.
Main Results:
- HOTAIR exhibits distinct expression patterns in various CVD contexts.
- HOTAIR circulates in the bloodstream and has epigenetic regulatory functions.
- Emerging evidence suggests HOTAIR's promise as a CVD biomarker and therapeutic target.
Conclusions:
- HOTAIR is significantly implicated in the pathogenesis of cardiovascular disorders.
- Further investigation into HOTAIR's molecular mechanisms is warranted.
- HOTAIR holds potential for future CVD diagnostics and treatments.
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