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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
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Behçet's disease modifies the gingival inflammatory response
Selin Sahinkaya1,2, Melis Yilmaz1,2, Ekin Yay1,2
1Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Türkiye.
Journal of Periodontology
|September 19, 2024
Summary
Behçet's disease (BD) impairs gingival health, leading to increased gingivitis severity. This study found higher plaque, probing depth, and bleeding in BD patients, indicating compromised oral health.
Area of Science:
- Oral Medicine
- Immunology
- Periodontology
Background:
- Behçet's disease (BD) is linked to systemic inflammation and severe outcomes.
- The impact of BD on gingival health and gingivitis severity requires further investigation.
Purpose of the Study:
- To test the hypothesis that BD negatively affects gingival health.
- To assess the severity of gingivitis in BD patients compared to controls.
Main Methods:
- 37 BD patients with gingivitis were compared to 19 healthy gingivitis patients and 20 healthy controls.
- Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing) were measured.
- Serum and saliva levels of inflammatory markers (ELA-2, SLPI, α1-AT, VEGF, IL-6, IL-8, TNF-α) were analyzed.
Main Results:
- BD patients exhibited significantly higher plaque index, probing pocket depth, and bleeding on probing than controls.
- Elevated IL-6 levels were observed in both serum and saliva of BD patients.
- Salivary ELA-2, TNF-α, and SLPI were higher in BD patients, while salivary α1-AT was lower compared to controls.
Conclusions:
- Gingival inflammatory profile is impaired in patients with Behçet's disease.
- BD negatively impacts oral health, contributing to increased gingivitis severity.
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