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Updated: Jun 12, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Synthesis, evaluation and modification of heterofunctional polyester dendrimers with internally queued bromide groups
Arunika Singh1, Daniel J Hutchinson1, Maria Isabel Montañez1
1Division of Coating Technology, Fiber and Polymer Technology, KTH, Teknikringen 48, Stockholm, SE-10044, Sweden. natsdo@kth.se.
Abstract:
Heterofunctional polyester dendrimers up to the third generation, containing 21 internally queued bromine atoms, have been successfully synthesized for the first time using a divergent growth approach. Direct azidation reactions enabled the conversion of the bromide groups to clickable azide pendant functionalities. Therapeutic and chemical moeities could then be coupled to the internal azide or bromide functionalities and external hydroxyl groups of the heterofunctional dendrimers through CuAAC, thiol-bromo click and esterification reactions, expanding their potential for biomedical applications.
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