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The Relationship Between Fibrinogen and Glycated Hemoglobin (HbA1c) in Diabetic Foot Ulcers

Kiran Notu1, Jayakumar Kt1, Raji Rajesh Lenin2

  • 1General Medicine, Sri Ramaswamy Memorial (SRM) Medical College Hospital and Research Centre, Kattankulathur, IND.

Cureus
|September 19, 2024
PubMed

Insights

Fibrinogen levels correlate with glycated hemoglobin (HbA1c) and predict glycemic control in diabetic foot ulcers (DFUs). This simple estimation aids in managing DFU patients and assessing peripheral arterial disease risk.

Area of Science:

  • Endocrinology
  • Vascular Medicine
  • Clinical Chemistry

Background:

  • Diabetic foot ulcers (DFUs) significantly impact patient quality of life and prognosis.
  • Effective management requires understanding complications like poor glycemic control and peripheral arterial disease.

Purpose of the Study:

  • To assess the correlation between fibrinogen and glycated hemoglobin (HbA1c) in DFU patients at 1 and 6 months.
  • To compare fibrinogen levels with the Wagner classification and ankle-brachial index (ABI) in DFU patients.

Main Methods:

  • Observational study of 50 DFU patients.
  • Collected blood samples for HbA1c, serum fibrinogen, hemoglobin, and WBC counts.
  • Analyzed data using ANOVA and Pearson's correlation.

Main Results:

  • Significant differences observed between fibrinogen and HbA1c levels (p < 0.0001).
  • Strong association found between fibrinogen levels and ABI scores (p < 0.0001).
  • Significant differences in fibrinogen noted at 1 and 6 months concerning HbA1c and ABI.

Conclusions:

  • Fibrinogen is a potential early marker for glycemic control in DFU patients.
  • Fibrinogen levels correlate with peripheral arterial disease markers (ABI).
  • Simple fibrinogen estimation can aid in predicting glycemic control and managing DFU complications.
Abstract

Keywords:
ankle-brachial indexdiabetic foot ulcerfibrinogenhba1cwagner classification

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