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  11. Sema7a As A Novel Prognostic Biomarker And Its Correlation With Immune Infiltrates In Breast Cancer

SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer

Shiyu Zhang1, Fanting Kong1, Lei Zheng1

  • 1Department of Breast Surgery, Xingtai People's Hospital, Xingtai, Hebei, 054000, People's Republic of China.

International Journal of General Medicine
|September 19, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Semaphorin 7a (SEMA7A) is elevated in breast cancer (BC) and linked to poorer survival. This study confirms SEMA7A as a potential prognostic biomarker, correlating with immune infiltration in BC patients.

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Semaphorin 7a (SEMA7A) role in cancer progression is known.
  • Prognostic significance of SEMA7A in breast cancer (BC) is unclear.

Purpose of the Study:

  • Evaluate SEMA7A's relationship with prognosis, immune invasion, and tumor mutation burden in various cancers.
  • Investigate SEMA7A expression, mutation, immune correlation, and coexpression in BC.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database for pancancer analysis.
  • Analyzed BC data using UAB Cancer data analysis portal, cBioPortal, and tumor immune estimation resource.
  • Performed survival analysis with Kaplan-Meier Plotter and generated ROC curves and nomograms using R software.

Main Results:

Keywords:
SEMA7Abioinformaticsbiomarkerbreast cancer

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  • Elevated SEMA7A expression correlates with poorer prognosis and higher tumor mutation burden across cancers.
  • SEMA7A is upregulated in BC, associated with immune infiltration.
  • High SEMA7A levels in BC patients correlate with shorter overall and distant metastasis-free survival.

Conclusions:

  • SEMA7A shows potential as a prognostic biomarker for breast cancer.
  • SEMA7A expression is significantly correlated with immune infiltration in breast cancer.
immune infiltration
methylation
nomogram
prognosis