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Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
Donor hepatectomy time and liver transplantation outcomes: An opportunity that cannot be dismissed
Francisca Gonzalez Cohens1, Fernando M Gonzalez2
1Web Intelligence Centre, Faculty of Physics and Mathematical Sciences, Universidad de Chile, Santiago 7500922, Chile.
Abstract:
The probability of developing primary dysfunction (PD) is a function of the probability of ischemia/reperfusion (I/R) injury. The probability of I/R injury in turn, is a function of several donor and transplantation process variables, among which is ischemia time. Custodio et al studied the duration of a special type of warm ischemia and showed, contrary to what is known, that a longer duration is not statistically different from a shorter one in PD development. This finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies, since the duration will not jeopardize liver transplant outcomes, albeit with some precautions.
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