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Correlation between circulating lipoprotein(a) levels and cardiovascular events risk in patients with type 2 diabetes

Jun-Xu Gu1, Juan Huang2, Kun Wang3

  • 1Department of Clinical Laboratory, Peking University People's Hospital, Beijing, PR China.

Heliyon
|September 19, 2024
PubMed

Insights

Elevated lipoprotein(a) [Lp(a)] levels are linked to increased coronary heart disease (CHD) severity and predict major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus (T2DM) patients. This finding highlights Lp(a) as a significant risk factor for cardiovascular complications in this population.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Clinical Research

Background:

  • High lipoprotein(a) [Lp(a)] concentration is associated with atherosclerosis.
  • The predictive value of Lp(a) for coronary heart disease (CHD) extent and major adverse cardiovascular events (MACEs) in diabetic patients is not fully understood.

Purpose of the Study:

  • To investigate if elevated Lp(a) exacerbates CHD in type 2 diabetes mellitus (T2DM) patients.
  • To assess the predictive utility of Lp(a) for MACEs in T2DM patients.

Main Methods:

  • Included 4332 T2DM patients who underwent coronary angiography (CAG).
  • Correlated Lp(a) levels with CHD severity using correlation analysis.
  • Evaluated MACEs using Cox regression analysis over a 7-year follow-up.

Main Results:

  • Lp(a) concentrations were significantly higher in the CHD group and correlated positively with disease severity.
  • Elevated Lp(a) is a risk factor for CHD occurrence (OR=1.597), vessel involvement (OR=1.908), and Gensini Score (OR=2.002).
  • Increased Lp(a) levels were independently associated with MACEs (HR=1.915).

Conclusions:

  • Confirmed a positive correlation between Lp(a) levels, CHD lesion count, and Gensini scores.
  • Lp(a) levels predict MACEs in T2DM patients, underscoring its clinical significance.
Abstract

Keywords:
Cardiovascular eventsCoronary heart diseaseRisk indicatorType 2 diabetes mellituslipoprotein(a)

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