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Updated: Jun 12, 2025

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Deciphering the role of PLCD3 in lung cancer: A gateway to glycolytic reprogramming via PKC-Rap1 activation

Liang Zhang1,2, Mingjiang Li2, Xiaoping Li2

  • 1Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China.

Heliyon
|September 19, 2024
PubMed

Insights

Phospholipase C delta 3 (PLCD3) promotes lung cancer growth and spread by activating the PKC-Rap1 pathway, leading to altered cell metabolism. Inhibiting PLCD3 may offer a new lung cancer treatment strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Phospholipase C delta 3 (PLCD3) is implicated in cell growth and death, but its role in lung cancer remains unclear.
  • Understanding PLCD3's function in lung cancer is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the role of PLCD3 in lung cancer development.
  • To explore the involvement of PLCD3 in glycolytic reprogramming via the protein kinase C (PKC)-dependent Rap1 signaling pathway.

Main Methods:

  • Analysis of PLCD3 expression in lung cancer tissues.
  • Investigating the activation of the PKC-Rap1 pathway by PLCD3.
  • Assessing the impact of PLCD3 on lung cancer cell proliferation, invasion, and metastasis.

Main Results:

  • PLCD3 expression is elevated in lung cancer tissues.
  • PLCD3 activation of the PKC-Rap1 pathway drives cancer cell proliferation and invasion.
  • PLCD3 promotes lung cancer metastasis by activating the Rap1 pathway, enhancing glycolytic reprogramming.

Conclusions:

  • PLCD3 plays a significant role in lung cancer progression by activating the PKC-Rap1 pathway and promoting metabolic reprogramming.
  • Targeting PLCD3, PKC, or the Rap1 pathway presents a potential therapeutic strategy for lung cancer treatment.
Keywords:
Lung cancerMetabolic reprogrammingPKCPLCD3Rap1 signaling pathway

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