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Updated: Jun 12, 2025
10:26
Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
Published on: November 7, 2019
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The Ubiquitin Tale: Current Strategies and Future Challenges
Arun Upadhyay1, Vibhuti Joshi2
1Department of Bioscience and Biomedical Engineering, Indian Institute of Technology Bhilai, Durg, Chhattisgarh 491001, India.
ACS Pharmacology & Translational Science
|September 19, 2024
Summary
Ubiquitin (Ub) and Ub-like modifications regulate key biological pathways. This review highlights ubiquitylome studies, their advancements, and challenges in understanding these crucial post-translational modifications in health and disease.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Ubiquitin (Ub) is a conserved protein crucial for physiological regulation.
- Ubiquitination, a post-translational modification, has diverse non-proteolytic functions.
- Ubiquitin-like proteins share structural and functional similarities with Ub.
Purpose of the Study:
- To review pathways, substrates, diseases, and therapeutic targets linked to ubiquitination and Ub-like modifications.
- To provide an overview of recent advancements in ubiquitylomic studies.
- To discuss the limitations and challenges in current ubiquitylomic research.
Main Methods:
- Literature review of ubiquitination and Ub-like modification research.
- Analysis of proteomic studies identifying ubiquitylomes.
- Evaluation of technological advancements in ubiquitylomics.
Main Results:
- Ubiquitination and Ub-like modifications are vital in modulating biological processes and the proteome.
- Proteomic studies have identified numerous ubiquitinated proteins under various conditions.
- Recent technological advancements enhance the understanding of global ubiquitination.
Conclusions:
- Ubiquitination and Ub-like modifications are critical regulators in cellular functions and disease pathogenesis.
- Large-scale ubiquitylomic studies are essential for comprehending ubiquitination in normal and pathological states.
- Addressing current technological limitations is key for future advancements in the field.
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