Related Experiment Video
Updated: May 7, 2026

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM
Published on: August 5, 2009
Probing diffusive media through speckle differencing
Muralidhar Madabhushi Balaji1,2, Danyal Ahsanullah1, Prasanna Rangarajan1,3
1Electrical and Computer Engineering, Lyle School of Engineering, Southern Methodist University, Dallas, Texas 75205, USA.
Abstract:
Temporally varying speckle patterns, produced by light-matter interaction encode valuable information about inhomogeneities embedded within a scattering medium. These speckle fluctuations arise either from the tuning of the emission frequency of a laser illuminating a static scattering medium or from the microscopic motion of scatterers within a dynamically scattering medium. In this work, we detect embedded inhomogeneities by probing static and dynamic scattering media with coherent light and leveraging the statistical distribution of temporal speckle differences. In addition, we utilize the insights from the speckle differencing paradigm, to present the first experimental results of detecting inhomogeneities embedded within a scattering medium using bio-inspired neuromorphic sensors. The proposed neuromorphic approach simplifies the optical and electronic design, and significantly reduces data throughput by capturing only the differential information in the form of 1-bit spikes.

