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The relationship between microRNAs and COVID-19 complications
Abdollah Kebriaei1, Reza Besharati1, Hasan Namdar Ahmad Abad1
1Department of Pathobiology and Laboratory Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Abstract:
Over the past three years, since the onset of COVID-19, several scientific studies have concentrated on understanding susceptibility to the virus, the progression of the illness, and possible long-term complexity. COVID-19 is broadly recognized with effects on multiple systems in the body, and various factors related to society, medicine, and genetics/epigenetics may contribute to the intensity and results of the disease. Additionally, a SARS-CoV-2 infection can activate pathological activities and expedite the emergence of existing health issues into clinical problems. Forming easily accessible, distinctive, and permeable biomarkers is essential for categorizing patients, preventing the disease, predicting its course, and tailoring treatments for COVID-19 individually. One promising candidate for such biomarkers is microRNAs, which could serve various purposes in understanding diverse forms of COVID-19, including susceptibility, intensity, disease progression, outcomes, and potential therapeutic options. This review provides an overview of the most significant findings related to the involvement of microRNAs in COVID-19 pathogenesis. Furthermore, it explores the function of microRNAs in a broad span of effects that may arise from accompanying or underlying health status. It underscores the value of comprehending how diverse conditions, such as neurological disorders, diabetes, cardiovascular diseases, and obesity, interact with COVID-19.
Insights
MicroRNAs show promise as biomarkers for understanding COVID-19 (coronavirus disease 2019) severity, progression, and outcomes. Research highlights their role in disease pathogenesis and interaction with comorbidities.
Area of Science:
- Biomedical Science
- Molecular Biology
- Genetics
Background:
- COVID-19 (coronavirus disease 2019) impacts multiple body systems, with severity influenced by societal, medical, and genetic factors.
- SARS-CoV-2 infection can exacerbate existing health conditions and trigger new pathological processes.
- Development of accessible biomarkers is crucial for patient stratification, prevention, prognosis, and personalized COVID-19 treatment.
Purpose of the Study:
- To review the significant findings on microRNA involvement in COVID-19 pathogenesis.
- To explore the role of microRNAs in the broader effects of COVID-19, considering comorbidities.
- To emphasize the importance of understanding microRNA interactions in conditions like neurological disorders, diabetes, cardiovascular diseases, and obesity alongside COVID-19.
Main Methods:
- Literature review of scientific studies on COVID-19 and microRNAs.
- Analysis of research focusing on microRNA roles in viral pathogenesis.
- Synthesis of findings regarding microRNA interactions with common comorbidities and COVID-19.
Main Results:
- MicroRNAs are implicated in the pathogenesis of COVID-19.
- MicroRNAs may influence disease susceptibility, intensity, progression, and outcomes.
- Understanding microRNA function is key to analyzing COVID-19's impact on patients with pre-existing conditions.
Conclusions:
- MicroRNAs represent promising biomarkers for COVID-19 management.
- Further research into microRNAs can elucidate COVID-19's complex interactions with various health conditions.
- Comprehending microRNA roles is vital for personalized medicine approaches to COVID-19.
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