The relationship between microRNAs and COVID-19 complications

Area of Science:

• Biomedical Science
• Molecular Biology
• Genetics

Background:

• COVID-19 (coronavirus disease 2019) impacts multiple body systems, with severity influenced by societal, medical, and genetic factors.
• SARS-CoV-2 infection can exacerbate existing health conditions and trigger new pathological processes.
• Development of accessible biomarkers is crucial for patient stratification, prevention, prognosis, and personalized COVID-19 treatment.

Purpose of the Study:

• To review the significant findings on microRNA involvement in COVID-19 pathogenesis.
• To explore the role of microRNAs in the broader effects of COVID-19, considering comorbidities.
• To emphasize the importance of understanding microRNA interactions in conditions like neurological disorders, diabetes, cardiovascular diseases, and obesity alongside COVID-19.

Main Methods:

• Literature review of scientific studies on COVID-19 and microRNAs.
• Analysis of research focusing on microRNA roles in viral pathogenesis.
• Synthesis of findings regarding microRNA interactions with common comorbidities and COVID-19.

Main Results:

• MicroRNAs are implicated in the pathogenesis of COVID-19.
• MicroRNAs may influence disease susceptibility, intensity, progression, and outcomes.
• Understanding microRNA function is key to analyzing COVID-19's impact on patients with pre-existing conditions.

Conclusions:

• MicroRNAs represent promising biomarkers for COVID-19 management.
• Further research into microRNAs can elucidate COVID-19's complex interactions with various health conditions.
• Comprehending microRNA roles is vital for personalized medicine approaches to COVID-19.