Related Experiment Video
Updated: Jun 12, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Can Serum Fetuin-A be Used as a Marker for Cardiovascular Involvement in Psoriatic Patients?
Hanan M Saleh1, Aliaa S Sheha2, Nardeen N Eskander1
1Dermatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Insights
Serum Fetuin A levels are significantly lower in psoriasis patients and negatively correlate with coronary artery calcification, indicating its potential as a biomarker for cardiovascular risk in psoriasis.
Area of Science:
- Cardiovascular Health
- Dermatology
- Biochemistry
Background:
- Psoriasis is a systemic inflammatory disease linked to increased cardiovascular disease risk.
- Fetuin A, a serum glycoprotein, may inhibit vascular calcification by forming calciprotein particles.
- Subclinical atherosclerosis is a concern in psoriatic patients.
Purpose of the Study:
- To measure serum Fetuin A levels in patients with psoriasis.
- To correlate serum Fetuin A levels with cardiac events and risks using coronary calcium scoring.
- To assess the relationship between Fetuin A, cardiovascular risk, and psoriasis severity.
Main Methods:
- Serum Fetuin A levels and coronary calcium scores were measured in 24 psoriatic patients and 24 controls.
- Psoriasis Area and Severity Index (PASI) scores were recorded.
- Correlations between serum Fetuin A, calcium scores, and PASI were analyzed.
Main Results:
- Psoriatic patients exhibited significantly lower serum Fetuin A levels compared to controls (P < .001).
- A significant negative correlation was observed between coronary calcium score and serum Fetuin A levels (P < .001).
- No significant correlation was found between serum Fetuin A levels and psoriasis severity.
Conclusions:
- Reduced serum Fetuin A levels are associated with psoriasis.
- Serum Fetuin A may serve as a valuable, accessible biomarker for detecting subclinical atherosclerosis in psoriatic individuals.
- Fetuin A levels correlate with cardiovascular risk markers in psoriasis patients.
Background:
Psoriasis is a systemic inflammatory disorder. It is associated with increased risk of developing other chronic health diseases such cardiovascular disorders. Fetuin A is a glycoprotein that is present in blood serum. It may prevent vascular calcification by forming calciprotien particles; which are formed from their attachment with phosphate and calcium complexes.
Aim:
The aim of this study was to measure serum Fetuin A in Psoriatic patients and correlate its level with cardiac events and risks in these patients using CT calcium (Ca) scoring.
Patients And Methods:
24 psoriatic patients (healthy without apparent cardiac risks to detect subclinical events if present) and 24 age and sex matched controls were tested for serum Fetuin A and underwent coronary calcium scoring by multidetector computed tomography (CT) scan. Psoriasis area and severity index (PASI) score for each patient was measured and was correlated with serum Fetuin A and CT calcium (Ca) scoring. Serum Fetuin A was compared between cases and controls and was correlated with coronary calcium score.
Results:
There was highly statistically significant decrease in serum Fetuin A level in psoriatic group compared to control group (P-value < .001). There was highly statistically significant negative correlation between calcium score and the level of serum Fetuin A (P-value < .001). No statistically significant correlation was found between the serum level of Fetuin A and the psoriasis severity.
Conclusion:
Serum Fetuin A is a simple, easy diagnostic tool to evaluate subclinical atherosclerosis in psoriatic patients.
More Related Videos
02:28Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
13:21Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
Published on: May 4, 2012
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...