Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin.

Area of Science:

• Nanotechnology
• Analytical Chemistry
• Biochemistry

Background:

• Curcumin (CUR), a turmeric-derived polyphenol, possesses various medicinal properties.
• CUR's inherent instability in aqueous solutions complicates its detection and application.
• Cyclodextrin-based nanogels (CyDngs) present a novel approach to stabilize CUR.

Purpose of the Study:

• To evaluate the efficacy of CyDngs in enhancing the stability of CUR.
• To develop and validate multisensing methods for sensitive CUR detection using CyDngs.
• To compare the performance of CyDngs with native beta-cyclodextrins (β-CyDs) for CUR stabilization and detection.

Main Methods:

• Preparation and characterization of cyclodextrin-based nanogels (CyDngs).
• Multisensing techniques including fluorescence, electrochemistry, and Nuclear Magnetic Resonance (NMR) spectroscopy.
• Langmuir adsorption isotherm analysis to determine binding constants.

Main Results:

• CyDngs significantly improved CUR's stability in aqueous solutions.
• Successful detection of CUR using fluorescence, electrochemistry, and NMR spectroscopy facilitated by CyDngs.
• Langmuir analysis yielded a binding constant of 1.4 × 10⁴ M^-1 for CyDngs, indicating strong CUR binding.

Conclusions:

• CyDngs are superior to native β-CyDs in stabilizing CUR.
• The developed CyDng-based multisensing platform enables reliable and sensitive CUR detection.
• This approach holds promise for advancing CUR-based diagnostics and therapeutics.