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Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress
Alec Simonson1, Akshay Naraine1,2, Samantha Maki3
1Department of Biological Sciences, Florida Atlantic University, Boca Raton, Florida, United States.
Micropublication Biology
|September 19, 2024
Abstract:
Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.

