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Evaluation of prognostic risk factors of triple-negative breast cancer with 18F-FDG PET/CT parameters, clinical pathological features and biochemical indicators

  • 0Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Frontiers in Cell and Developmental Biology +

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September 19, 2024

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September 19, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies key prognostic factors for triple-negative breast cancer (TNBC) survival. Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (<sup>18</sup>F-FDG PET/CT) parameters and specific biochemical indicators can predict disease-free and overall survival in TNBC patients.

Area Of Science

  • Oncology
  • Medical Imaging
  • Biochemistry

Background

  • Triple-negative breast cancer (TNBC) is a challenging subtype with distinct biological behaviors.
  • Identifying reliable prognostic factors for TNBC is crucial for improving patient outcomes.
  • <sup>18</sup>F-FDG PET/CT parameters and biochemical indicators are potential prognostic markers.

Purpose Of The Study

  • To evaluate <sup>18</sup>F-FDG PET/CT parameters, clinical pathological features, and biochemical indicators as prognostic risk factors for TNBC.
  • To explore correlations between biochemical indicators and <sup>18</sup>F-FDG PET/CT parameters in TNBC patients.

Main Methods

  • Retrospective analysis of 95 TNBC patients who underwent preoperative <sup>18</sup>F-FDG PET/CT.
  • Kaplan-Meier survival analysis and multivariate Cox regression to assess associations with disease-free survival (DFS) and overall survival (OS).
  • Spearman correlation coefficient used to analyze relationships between quantitative variables.

Main Results

  • Mean standardized uptake value (SUV<sub>mean</sub>) was significantly correlated with DFS.
  • Fasting blood glucose (FBG), α- L-fucosylase (AFU), and Creatine kinase (CK) independently predicted DFS.
  • Precursor albumin (PALB) and CK independently predicted OS. FBG and CK correlated with <sup>18</sup>F-FDG PET/CT parameters.

Conclusions

  • <sup>18</sup>F-FDG PET/CT parameters (SUV<sub>mean</sub>) and biochemical indicators (FBG, AFU, CK, PALB) are significant predictors of DFS and OS in TNBC patients.
  • These findings suggest potential utility in developing a novel prognostic model for post-surgery TNBC management.
  • Clinical attention to these indicators may enhance personalized treatment strategies for TNBC.

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