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Updated: Jun 12, 2025
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Correlation between Carotid Artery Mean Intima-Media Thickness and brain Natriuretic Peptide in Patients with
Nasim Niknezhad1, Mohammad Shahidi-Dadras1, Fateme Rajabi1,2
1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background:
Numerous studies have documented an association between psoriasis and subclinical atherosclerosis.
Objective:
We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery.
Methods:
Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence.
Results:
Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups.
Conclusions:
In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis.
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