Related Experiment Video

Updated: Jun 12, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

14.9K

Roles of DEPDC1 in various types of cancer (Review)

Danqi Liu1,2, Haima Li3, Jia Ouyang2

  • 1School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100044, P.R. China.

Oncology Letters
|September 19, 2024
PubMed

Insights

Dishevelled, EGL-10 and pleckstrin domain-containing 1 (DEPDC1) is highly expressed in tumors, driving cancer progression and linked to poor prognosis. Targeting DEPDC1 shows promise for cancer diagnostics, therapeutics, and vaccines.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Dishevelled, EGL-10 and pleckstrin domain-containing 1 (DEPDC1) is a protein.
  • DEPDC1 is largely undetectable in normal tissues but highly expressed in various tumor types.
  • DEPDC1 plays a significant role in cell mitosis, proliferation, migration, invasion, angiogenesis, autophagy, and apoptosis.

Purpose of the Study:

  • To provide a comprehensive review of DEPDC1's role in cancer.
  • To consolidate existing knowledge on DEPDC1 in cancer biology.
  • To identify gaps in understanding DEPDC1's complex interactions in cancer.

Main Methods:

  • Literature review and critical analysis of existing studies on DEPDC1 in cancer.
  • Examination of DEPDC1's involvement in key signaling pathways (NF-κB, PI3K/Akt, Wnt/β-catenin, Hippo).
  • Analysis of DEPDC1 expression correlation with prognosis and survival rates in various cancers.

Main Results:

  • DEPDC1 expression is linked to poor prognosis and survival in hepatocellular carcinoma, lung adenocarcinoma, colorectal cancer, and breast cancer.
  • DEPDC1 is implicated in critical cell proliferation and survival pathways.
  • DEPDC1 shows potential as a diagnostic and prognostic marker and a therapeutic target.

Conclusions:

  • DEPDC1 is a crucial factor in cancer development and progression.
  • Targeting DEPDC1 may inhibit tumor growth and metastasis, improving patient outcomes.
  • DEPDC1-derived peptide vaccines demonstrate safety and potential efficacy in clinical trials.
Keywords:
EGL-10 and pleckstrin domain-containing 1cancerdishevelledmolecular mechanismpeptide vaccinesignaling pathway

More Related Videos

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.2K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

740

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.5K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.2K
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
2.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K