A theoretical study on evaluating brain tumor changes in tumor treating fields therapy by impedance detection

Area of Science:

• Biomedical Engineering
• Oncology
• Medical Physics

Background:

• Tumor Treating Fields (TTFields) is an FDA-approved therapy for glioblastoma multiforme (GBM).
• Current efficacy assessment relies on infrequent MRI scans (two-month intervals).
• Electrical impedance changes reflect tissue property alterations, crucial for monitoring tumor status.

Purpose of the Study:

• To investigate the feasibility of using TTFields electrodes as sensors for real-time impedance monitoring during GBM treatment.
• To determine if impedance measurements can continuously assess treatment effectiveness.

Main Methods:

• An in silico study was conducted to validate the hypothesis.
• Electrical impedance was measured between opposing TTFields electrode arrays.
• Simulated TTFields treatment parameters (50 V, 200 kHz) were utilized.

Main Results:

• The proposed impedance detection technique demonstrated sufficient resolution (> 1mm) to detect tumor size changes.
• A high Signal-to-Noise Ratio (> 40 dB) was achieved, indicating reliable measurements.
• The feasibility of using TTFields electrodes for continuous monitoring was confirmed.

Conclusions:

• Impedance measurement using TTFields electrodes is a viable method for real-time assessment of GBM treatment.
• This technique can potentially augment TTFields therapy by providing continuous safety and efficacy evaluation.
• This approach may lead to more adaptive and personalized cancer treatment strategies.