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Updated: Jun 12, 2025

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Developing non-radioactive, radical methods to screen for radiolytic stability
Brandon G Wackerle1, Madison R Vicente1, Fatema Tuz Zohara1
1Department of Chemistry, Clemson University, Clemson, SC 29634-0973, USA. brumagh@clemson.edu.
Abstract:
Radiolytically generated radicals cause degradation of nutrients in food, materials in satellites and solar cells, and human health. Radiation effects are studied using gamma radiolysis, a low-throughput, high-cost, and low-accessibility method. We developed a higher-throughput, low-cost, non-radioactive, radical assay that produces radicals similar to those generated in gamma radiolysis and examined monoamide degradation. Our radical assay results correspond to those from gamma irradiation in both monoamide stability and decomposition products, establishing this radical assay as a proof-of-concept screening tool for radiolytic stability.
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