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Updated: Jun 12, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Quizartinib: a new hope in acute myeloid leukemia, an applied comprehensive review
Fatemeh Esmaeilpour Moallem1, Mohammad Sadra Gholami Chahkand1, Parisa Alsadat Dadkhah2
1Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
Abstract:
Acute myeloid leukemia (AML) is caused by a defective precursor leading to malignant clonal expansion, often with FMS-like tyrosine kinase-3 receptor (FLT3) mutations, particularly internal tandem duplication (ITD), which has a poor prognosis. Quizartinib, a second-generation FLT3 inhibitor, has FDA approval for relapsed/refractory AML with FLT3/ITD mutation. It has shown promise in clinical studies since 2013 due to its excellent oral absorption and potent activity on FLT3. This review explores Quizartinib's mechanism of action, efficacy in monotherapy or combination with chemotherapy, drug interactions, adverse events, resistance mechanisms and future research directions.
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