The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media

Area of Science:

• Computational biology
• Biophysics
• Scientific computing

Background:

• Excitable media simulations are crucial for understanding cardiac electrophysiology.
• Efficient computational tools are needed to model complex wave phenomena in cardiac tissue.
• Open-source solutions promote collaboration and reproducibility in scientific research.

Purpose of the Study:

• Introduce Ithildin, an open-source C++ library for parallelized simulations of excitable media.
• Demonstrate the capabilities of Ithildin using cardiac electrophysiology models.
• Highlight Ithildin's potential for advancing research in cardiac wave dynamics.

Main Methods:

• Developed Ithildin as an open-source C++ framework.
• Implemented parallelization using the Message Passing Interface (MPI) for multi-CPU processing.
• Performed simulations of cardiac electrophysiology, including S1S2 protocols, spiral break-up, and spiral waves in ventricular geometry.

Main Results:

• Successfully simulated complex wave patterns in cardiac tissue using Ithildin.
• Demonstrated the library's versatility across various electrophysiology scenarios.
• Validated Ithildin's efficiency and capability for parallelized simulations.

Conclusions:

• Ithildin is a powerful, open-source tool for simulating excitable media, particularly cardiac electrophysiology.
• The framework facilitates the study of complex wave phenomena, aiding future experimental and theoretical investigations.
• The open-source nature of Ithildin supports scientific transparency and collaborative research.