Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

364
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
364
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Podcast: Immune Persistence After Primary Vaccination with MenQuadfi.

Infectious diseases and therapy·2026
Same author

mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae.

PLoS genetics·2026
Same author

IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster.

BMC biology·2026
Same author

High-Flow Oxygen Therapy vs. Continuous Positive Airway Pressure in Hospitalised Bronchiolitis: A Meta-Analysis.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Altered behaviour and immune response in mice with NHLRC2 p.Asp148Tyr variant.

Brain, behavior, & immunity - health·2025
Same author

Five-Year Immune Persistence of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) and Immunogenicity and Safety of a Booster Dose in Children.

Infectious diseases and therapy·2025

Related Experiment Video

Updated: Jun 12, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

7.9K

Genetic Susceptibility to Acute Viral Bronchiolitis.

Anu Pasanen1,2,3, Minna K Karjalainen2,4, Matti Korppi5,6

  • 1Research Unit of Clinical Medicine, University of Oulu.

The Journal of Infectious Diseases
|September 19, 2024
PubMed
Summary

Genetic variants in CDHR3 and GSDMB influence susceptibility to infant bronchiolitis, particularly non-RSV infections. Severe infant bronchiolitis may indicate a genetic predisposition to developing asthma.

Keywords:
CDHR3GSDMBasthmabronchiolitisgenetic risk factors

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.3K
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

30.1K

Related Experiment Videos

Last Updated: Jun 12, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

7.9K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.3K
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

30.1K

Area of Science:

  • Genetics
  • Pediatrics
  • Respiratory Medicine

Background:

  • Acute viral bronchiolitis is a significant cause of infant hospitalization globally.
  • Bronchiolitis in childhood is a recognized risk factor for asthma, implying shared genetic and biological underpinnings.
  • Identifying genetic risk loci can illuminate bronchiolitis pathogenesis.

Purpose of the Study:

  • To investigate the genetic factors contributing to bronchiolitis susceptibility using genome-wide association studies (GWAS).
  • To explore the relationship between infant bronchiolitis and the later development of asthma.

Main Methods:

  • Conducted a genome-wide association study (GWAS) within the FinnGen project.
  • Analyzed data from 1,465 infants hospitalized with bronchiolitis (<2 years) and 356,404 controls without a history of acute lower respiratory infections.

Main Results:

  • GWAS identified significant associations (p<5×10-8) for variants in GSDMB and CDHR3.
  • Infants hospitalized for bronchiolitis showed a higher likelihood of developing asthma later in life.
  • Associated loci were previously linked to asthma and wheezing, with stronger effects observed in non-RSV bronchiolitis.

Conclusions:

  • Genetic variants in CDHR3 and GSDMB appear to modulate bronchiolitis susceptibility, especially for non-RSV infections.
  • Severe infant bronchiolitis might trigger asthma development in genetically predisposed individuals or serve as a marker for this predisposition.