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Updated: Jun 12, 2025

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Artificial design of the genome: from sequences to the 3D structure of chromosomes
Jun-Yi Wang1, Ze-Xiong Xie1, You-Zhi Cui1
1Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Frontiers Research Institute for Synthetic Biology, Tianjin University, Tianjin 300072, China.
Abstract:
Genome design is the foundation of genome synthesis, which provides a new platform for deepening our understanding of biological systems by exploring the fundamental components and structure of the genome. Artificial genome designs can endow unnatural genomes with desired functions. We provide a comprehensive overview of genome design principles ranging from DNA sequences to the 3D structure of chromosomes. Furthermore, we highlight applications of genome design in gene expression, genome structure, genome function, and biocontainment, and discuss the potential of artificial intelligence (AI) in genome design.
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